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There are several forms of hair loss that seem to be mediated by autoimmune processes. At present time, there have been several animal studies conducted to investigate a link between vitamin B1 and autoimmunity. In general, these studies have suggested that vitamin B1 deficiencies may exacerbate autoimmunity in certain autoimmune disorders – specifically, multiple sclerosis (3, 4).
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Also, a 2015 case-control study found a relation between those who had alopecia and high blood sugar levels. There have been a few isolated reports of hair loss in people taking metformin. In one report, a person with type 2 diabetes who took metformin and another diabetes drug, sitagliptin, experienced eyebrow and eyelash hair loss. It’s possible that this was a medication-related side effect, but this isn’t entirely clear. Metformin (metformin hydrochloride) is a drug commonly prescribed to people with type 2 diabetes or hyperglycemia.
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Maintaining homeostasis—and by extension the proper concentration of active metabolite—is important for healthy hair [18]. Benfotiamine inhibits what are known as advanced glycation end-products (AGEs), which are markers for diabetic complications. Because thiamine deficiency is also known to cause nerve pain, in theory, supplementing with benfotiamine could alleviate some symptoms of neuropathy. Some proponents claim that biotin-containing products make your hair stronger and more luscious.
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These results also suggest that vitamin D supplements or topical vitamin D analogues should be considered for patients with AA and vitamin D deficiency. However, the meta-analysis did not find any clear correlations between extent of hair loss and serum 25-hydroxyvitamin D level [68]. Alopecia areata (AA) occurs when the immune system attacks the hair follicle.
Does Smoking Cause Biotin Deficiency?
Smoking leads to endothelial dysfunction, an early event in cardiovascular disease. In a preclinical study on rats, benfotiamine was found to prevent nicotine-induced vascular dysfunction. A trial conducted on healthy volunteers has demonstrated that short-term treatment with benfotiamine can partly restore macrovascular function in healthy smokers. Thiamine, also known as vitamin B1, plays a vital role in energy metabolism and the degradation of sugars and carbon skeletons; it is also involved in neuronal communication and activation of the immune system. The association of thiamine with these vital functions makes it an important dietary nutrient. Reduced thiamine intake results in impaired energy metabolism, increased cellular oxidative stress, and neurological side effects.
Importantly, benfotiamine was effective in suppressing cognitive decline, as measured by Alzheimerˈs disease assessment scale and clinical dementia rating. These encouraging results warrant a larger clinical trial to confirm these findings. Regarding benfotiamine treatment in the pre- and post-treated groups, animals showed a significant reduction and normalization of tissue MDA content. Similarly, benfotiamine pre-treatment group revealed a significant increase in myocardial GSH content while benfotiamine post-treatment completely improved perturbations of GSH content. Benfotiamine was previously shown to improve the antioxidant capacity in addition to the reduction of lipid peroxidation in different experimental models [12,34–36]. Additionally, it was stated that benfotiamine reduced oxidative stress, activated eNOS and subsequently improved the integrity of vascular endothelium in experimentally-induced vascular endothelial dysfunction [37].
vitamin and mineral deficiencies
Hair loss, or alopecia, affects more than 80 percent of men and 50 percent of women, and the risk increases with age. In the current clinical trial, side effects were deemed minimal and manageable. Another oral drug for alopecia, called baricitinib, was approved by the FDA in 2022 to exclusively treat adults. If your institution or institutions have a press office, please notify them about your upcoming paper at this point, to enable them to help maximize its impact.
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Benfotiamine: Uses, Benefits, Side Effects, Dosage - Verywell Health
Benfotiamine: Uses, Benefits, Side Effects, Dosage.
Posted: Tue, 21 Feb 2023 08:00:00 GMT [source]
The current study was designed to examine the beneficial effects of benfotiamine on myocardial damage when used as pre- and post-treatments in ISO-induced MI in rats. ISO-A and ISO-B groups involved in the current study displayed obvious inflammation, imbalance in oxidant/antioxidant markers and cardiac damage, which were confirmed by biochemical and histopathological examinations. Of these, 90% are in the anagen phase, where there is no alopecia, requiring essential elements, such as proteins, vitamins, and minerals, to efficiently produce healthy hair [3, 4].
Biotin Side Effects
View our Hair Loss Success Stories, which includes the world's largest gallery of hair growth photos and demonstrates the level of success that so many of Belgravia's patients achieve. At the same time, there could be a small minority of B1 deficiencies that go undetected, as was the case with the case series of Hashimoto’s thyroiditis patients. So, if you find yourself with fatigue that isn’t responding to standard treatment for Hashimoto’s thyroiditis, it may be worth discussing the possibility of vitamin B1 supplementation with your doctor. So, it’s possible that vitamin B1 doesn’t increase NADPH beyond what’s considered normal.
It is usually manifested with severe dermatitis and alopecia, where there is loss of vellus and terminal hair on the scalp; eyebrows, eyelashes, and lanugo hair can also be absent. The infantile form of biotin deficiency occurs after 3 months of delivery and is due to a lack of the enzyme called biotinidase. In this form, hair of the scalp, eyebrows, and eyelashes is sparse or totally absent [34]. Food and Drug Administration, biotin interference (from supplemental biotin) caused a falsely low result in a troponin test that led to a missed diagnosis of a heart attack and a patient’s death [28]. In addition, a recent study showed that some human chorionic gonadotropin (hCG) devices are subject to biotin interference in individuals taking dietary biotin supplements. Therefore, clinicians and laboratory technicians need to be aware of this potential interference with qualitative urine hCG tests and should suggest quantitative serum hCG measurement.
An outbreak of selenium toxicity from a liquid dietary supplement that contained 200-fold the labeled concentration of selenium resulted in severe hair loss in most patients [121]. Vitamin D is a fat-soluble vitamin synthesized in epidermal keratinocytes [53]. Vitamin D obtained from the diet or synthesis in skin is inactive and needs to be activated enzymatically.
Studies have shown its antioxidant and anti-inflammatory potential in activated immune and glial cells. It also improves complications observed in type 2 diabetes and has beneficial effects in mouse models of neurodegenerative disease. Benfotiamine represents an off-the-shelf agent used to support nerve health, promote healthy aging and support glucose metabolism. Accordingly, the present review aimed to provide an overview of the neuroprotective effects of thiamine/benfotiamine in the context of inflammation and oxidative stress. In the current study, pre- and post-treatments with benfotiamine revealed marked protection and normalization of PKC and NF-κB contents. Likewise, the benfotiamine pre-treatment normalized MMP-9 content, while the post-treated group showed only a significant reduction of its content compared to ISO-B group.
Some immune-suppressing drugs used to treat autoimmune conditions like lupus and rheumatoid arthritis can cause hair loss. A few of these include methotrexate, leflunomide (Arava), cyclophosphamide (Cytoxan), and etanercept (Enbrel). When hemoglobin is too low, you can become anemic and lose hair as a result. This occurs in the “resting” phase of the hair follicle, but new hair growth continues. A small clinical trial conducted at the Burke Neurological institute concluded that benfotiamine is safe and potentially effective at improving cognitive outcomes in those suffering from mild Alzheimer’s. Benfotiamine raises vitamin B1 levels, which improves brain glucose utilization.
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